OBJECTIVES Acute kidney injury (AKI) is a common complication of cardiovascular surgery that is associated with increased mortality, especially after surgeries involving the aorta. Early detection and prevention of AKI in patients with aortic dissection may help improve outcomes. The objective of this study was to develop a practical prediction score for AKI after surgery for Stanford type A acute aortic dissection (TAAAD). METHODS This was a retrospective cohort study that included 2 independent hospitals. A larger cohort of 326 patients from The Second Hospital of Jilin University was used to identify the risk factors for AKI and to develop a risk score. The derived risk score was externally validated in a separate cohort of 102 patients from the other hospital. RESULTS The scoring system included the following variables (i) age &gt;45?years; (ii) body mass index &gt;25?kg/m2; (iii) white blood cell count &gt;13.5?×?109/l; and (iv) lowest perioperative haemoglobin 150?min and renal malperfusion. On receiver operating characteristic curve analysis, the score predicted AKI with fair accuracy in both the derivation [area under the curve 0.778, 95% confidence interval (CI) 0.726-0.83] and the validation (area under the curve 0.747, 95% CI 0.657-0.838) cohorts. CONCLUSIONS We developed a convenient scoring system to identify patients at high risk of developing AKI after surgery for TAAAD. This scoring system may help identify patients who require more intensive postoperative management and facilitate appropriate interventions to prevent AKI and improve patient outcomes. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.The present study aimed to evaluate the effects of long-term storage at different temperatures (4, 25 and 35&nbsp;°C) on flavor, microbiological and physicochemical quality characteristics of low-salt fermented fish. Food spoilage and pathogenic bacteria, such as coliforms,&nbsp; Pseudomonas ,&nbsp; Salmonella , were inhibited during the&nbsp;90 days of storage at all temperatures. Lactic acid bacteria, yeast and total viable counts of the samples stored at 35 °C reduced sharply while others were stable. Compared to refrigerated storage (4 °C), higher storage temperatures (25 and 35 °C) accelerated the moisture migration, lipid oxidation and proteolytic degradation. Compared with storage temperature, storage time contributed more largely to the increase of volatile compounds of Suanyu. Refrigerated storage was beneficial in maintaining odors quality of Suanyu during the whole storage compared with higher storage temperatures (25 and 35 °C). Total biogenic amines contents in all the samples were far below 200 mg/kg.&nbsp;Fermented fish can be consumed with safety during 90 days of storage based on spoilage and pathogenic bacteria and biogenic amines, but the refrigerated storage could effectively slow down the microbial&nbsp;and&nbsp;physicochemical&nbsp;changes to obtain better&nbsp;organoleptic quality.&nbsp;This study will be beneficial to control the safety and quality of fermented fish during transport and storage.Colon cancer side population (SP) cells are a small subset of cancer cells that have cancer stemness capacity and enhanced drug resistance. ABCG2 is a multidrug resistance-related protein in SP cells, and has been demonstrated to be regulated by Notch signaling pathway. Recently, microRNAs are reported to play a critical role in SP cell fate. However, their role in ABCG2-mediated drug resistance in colon cancer SP cells remains unclear. In the current study, the different expressions of miR-552, miR-611, miR-34a, and miR-5000-3p were compared within SP and non-SP cells, which were separated from human colon cancer cell lines (SW480 and LoVo). We found that miR-34a was significantly downregulated in SP cells, and that overexpressing miR-34a overcame drug resistance to 5-FU. The luciferase reporter assay indicated that miR-34a negatively regulated DLL1, a ligand of Notch signaling pathway, via binding with 3'-UTR of its mRNA. In addition, overexpressing miR-34a overcame ABCG2-mediated resistance to 5-FU via DLL1/Notch pathway in vitro, and suppressed tumor growth under 5-FU treatment in vivo. In conclusion, our findings suggest that miR-34a acts as a tumor suppressor via enhancing chemosensitivity to 5-FU in SP cells, which provides a novel therapeutic target in chemotherapy-resistant colon cancer. © The Author(s) 2020. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.In 2012, the Spanish government enforced a healthcare exclusion policy against undocumented immigrants. The newly elected government has recently derogated this policy. https://www.selleckchem.com/ To analyze how this decree could have affected population health, we looked at primary health patients who would have been excluded and compared with a matched sample of non-excluded patients. Potentially excluded patients had decreased odds of depression, chronic obstructive pulmonary disease, dyslipidaemia, heart failure and hypertension while diabetes mellitus rates were similar to non-excluded. Infectious diseases were more frequent in potentially excluded population (HIV, tuberculosis and syphilis). The exclusion of patients impedes the control of infectious diseases at a community level. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.BACKGROUND Long-term mortality after hematopoietic cell transplantation (HCT) is conventionally calculated from the time of HCT, ignoring temporal changes in survivors' mortality risks. Conditional survival rates, accounting for time already survived, are relevant for optimal delivery of survivorship care, but have not been widely quantified. We estimated conditional survival by elapsed survival time in allogeneic HCT patients and examined cause-specific mortality. METHODS We calculated conditional survival rates and standardized mortality ratio (SMR) for overall and cause-specific mortality in 4485 patients who underwent HCT for malignant hematologic diseases at a large transplant center during 1976-2014. Statistical tests were two-sided. RESULTS The 5-year survival rate from HCT was 48.6%. After surviving 1, 2, 5, 10, and 15 years, the subsequent 5-year survival rates were 71.2%, 78.7%, 87.4%, 93.5%,86.2%, respectively. The SMR was 30.3 (95% CI?=?29.2 to 35.5). Although SMR declined in longer surviving patients, it was still elevated by 3.